The treatment options for von Willebrand\’s Disease include Tranexamic Acid (Cyklokapron), Desmopressin (DDAVP), von Willebrand\’s Factor replacement therapy and fibrin glue.
Tranexamic Acid (Cyklokapron)
Tranexamic acid slows the breakdown of blood clots. It is used to prevent or treat bleeding from mucous membranes, such as the inside of the mouth, nose, gut or uterus. It may be given before dental work, for nose bleeds or prolonged menstrual bleeding.
Desmopressin (DDAVP)
Desmopressin (DDAVP) is a synthetic hormone which is not made from blood products. Administration of DDAVP is made by intravenous infusion over approximately 30 minutes. A test dose is always given at diagnosis to document a positive response. DDAVP is also available as a nasal spray which is recommended for home use. Sometimes a person does not respond as expected to DDAVP. In this situation, plasma-derived factor containing factor VIII and von Willebrand\’s factor must be used.
von Willebrand\’s Factor Replacement Therapy
Factor VIII / von Willebrand\’s Factor (vWF) concentrate is given into a vein to replace the missing vWF to allow clotting to take place. It is made from pooled human plasma, which is screened for blood-borne viruses.
Fibrin Glue
Fibrin glue is made from synthetic copies of two proteins: fibrinogen and thrombin, which are normally found in the body. Fibrin glue can be put directly to the site of bleeding. It is especially useful in tooth extractions.