When a person with haemophilia or related bleeding disorder develops an inhibitor, it can take some time to stop the inhibitor. There have been significant advances in the treatment of bleeds when inhibitors are present and the outlook has dramatically improved. The choice of treatment will depend on a number of factors, such as the severity of the bleed, and whether or not the individual is a “high” or “low responder”. A low responder is someone with a low level of inhibitor in order to control a bleed, more frequent infusions and higher doses of clotting factor replacement therapy may be sufficient. However, in more severe bleeds, or where the individual is a “high” responder, advanced therapies known as bypassing agents are usually required to control the bleeding. Bypassing agents are so called because they work around the inhibitors and help the blood to clot.
Your Haemophilia Treatment Centre will advise you on how to treat bleeds. If you have any concerns that a bleed is not responding to the treatment, you should contact your Haemophilia Treatment Centre straight away for advice.